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A serving bowl full of Instant Pot Mississippi Pot Roast.

Instant Pot Mississippi Pot Roast

Tressa Jamil
Instant Pot Mississippi roast is the ultimate comfort food. Chuck roast sears to a golden brown- then pressure-cooks with pepperoncinis and tangy, homemade ranch until it's tender enough to be shredded and served.
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Prep Time 10 mins
Cook Time 1 hr 20 mins
Total Time 1 hr 30 mins
Course Main Course
Cuisine American
Servings 8 Servings
Calories 421 kcal


For the Roast:

  • ¼ cup flour
  • 2 teaspoon kosher salt
  • teaspoon black pepper, coarse ground
  • 1 ½ tablespoon avocado oil
  • 3 pound chuck roast
  • 4 tablespoon unsalted butter
  • 1 jar whole pepperoncinis, drained
  • 1 yellow onion, finely sliced

For the Homemade Ranch:

  • 4 tablespoons mayonnaise
  • 4 tablespoons sour cream
  • 1 teaspoon fresh dill, finely chopped
  • 1 teaspoon fresh parsley, finely chopped
  • 1 teaspoon lemon juice
  • 1 tablespoon garlic, minced, about four cloves
  • ½ teaspoon garlic powder
  • ½ teaspoon onion powder
  • ½ teaspoon red pepper flakes


  • Combine flour, salt, and pepper in a mixing bowl; cover the roast with the mixture.
  • Warm oil in an Instant Pot on saute mode. Then, add the roast and brown the meat on all sides, 4-5 minutes per side to create a crust.
  • Add butter, onions, and pepperoncini's, then place the lid on the pot, but do not secure it. Let it simmer for 5 minutes.
  • Meanwhile, prepare the ranch dressing. Combine the ingredients for the ranch dressing in a small bowl and whisk to emulsify.
  • Remove the lid and add the ranch dressing.
  • Secure the lid, and set the Instant Pot to manual high pressure. Allow the meat to cook for 70 minutes with a quick release. When it's done, let it rest on a cutting board for about 5 minutes.
  • Shred the roast, and then add it to a serving dish with some liquid from inside the Instant Pot.
  • Serve the Mississippi roast as is, or throw it all on a hoagie with provolone cheese and a side of au jus.


  • Sear the roast cooking it in the pressure cooker. You can skip this step if you're in a hurry, but taking the time to do so imparts flavor.
  • Do not try this recipe with other cuts of meat! Ask me how I know that! Any beef labeled as chuck will work for this recipe.
Nutrition Disclosure:
  • The nutritional information shown is an estimate provided by an online nutrition calculator. It should not be considered a substitute for professional advice.
Web Story: 
  • Check out my web story for Instant Pot Mississippi Roast. 


Serving: 0.5 CupCalories: 421kcalCarbohydrates: 7gProtein: 51gFat: 22gSodium: 1301mgFiber: 2gSugar: 1g
Keyword instant pot mississippi pot roast, mississippi pot roast
Did you make this recipe? Let me know how it turned out for you! Leave a comment below and follow @thejamilghar or tag #thejamilghar on Instagram!